A year after the death of his friend and partner Sherlock Holmes at the hands of Moriarty, Dr. John Watson resumes his medical career as the head of a clinic dedicated to treating rare disorders. However, he soon finds that his old life is not done with him yet.
After her successful career in Chicago, Elsbeth Tascioni, an astute but unconventional attorney, utilizes her singular point of view to make unique observations and corner brilliant criminals alongside the NYPD.
Patrick Jane, a former celebrity psychic medium, uses his razor sharp skills of observation and expertise at "reading" people to solve serious crimes with the California Bureau of Investigation.
Lone-wolf survivalist Colter Shaw roams the country as a “reward seeker,” using his expert tracking skills to help private citizens and law enforcement solve all manner of mysteries while contending with his own fractured family.
Samantha and Jay throw caution to the wind when they convert their recently inherited country estate into a bed-and-breakfast. Call it mislaid plans. Not only is the place falling apart, but it’s also inhabited by spirits of previous residents -- whom only Samantha can see and hear.