A year after the death of his friend and partner Sherlock Holmes at the hands of Moriarty, Dr. John Watson resumes his medical career as the head of a clinic dedicated to treating rare disorders. However, he soon finds that his old life is not done with him yet.
Morgan is a single mom with an exceptional mind, whose unconventional knack for solving crimes leads to an unusual and unstoppable partnership with a by-the-book seasoned detective.
Adrian Monk was once a rising star with the San Francisco Police Department, legendary for using unconventional means to solve the department's most baffling cases. But after the tragic (and still unsolved) murder of his wife Trudy, he developed an extreme case of obsessive-compulsive disorder. Now working as a private consultant, Monk continues to investigate cases in the most unconventional ways.
Patrick Jane, a former celebrity psychic medium, uses his razor sharp skills of observation and expertise at "reading" people to solve serious crimes with the California Bureau of Investigation.
John Taylor lives in quiet solitude, designing puzzles for a living, under the nom-de-plume of 'Ludwig'. When his identical twin, James, disappears off the face of the earth, John takes over his brother's identity in a quest to discover his whereabouts.