Former London constable Nicholas Angel finds it difficult to adapt to his new assignment in the sleepy British village of Sandford. Not only does he miss the excitement of the big city, but he also has a well-meaning oaf for a partner. However, when a series of grisly accidents rocks Sandford, Angel smells something rotten in the idyllic village.
Twenty-eight weeks after the spread of a deadly rage virus, the inhabitants of the British Isles have lost their battle against the onslaught, as the virus has killed everyone there. Six months later, a group of Americans dare to set foot on the Isles, convinced the danger has passed. But it soon becomes all too clear that the scourge continues to live, waiting to pounce on its next victims.
A woman brings her family back to her childhood home, which used to be an orphanage, intent on reopening it. Before long, her son starts to communicate with a new invisible friend.
In one of Paris's finest restaurants, Remy, a determined young rat, dreams of becoming a renowned French chef. Torn between his family's wishes and his true calling, Remy and his pal Linguini set in motion a hilarious chain of events that turns the City of Lights upside down.
Bourne is brought out of hiding once again by reporter Simon Ross who is trying to unveil Operation Blackbriar, an upgrade to Project Treadstone, in a series of newspaper columns. Information from the reporter stirs a new set of memories, and Bourne must finally uncover his dark past while dodging The Company's best efforts to eradicate him.